Is it possible to just switch from zoloft to effexor without weaning off the zoloft. I am currently on 125 mg of zoloft and my dr. wants me to switch for help with migraines as well as depression. Can this be done, and if so, at what dose?
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replied August 30th, 2012
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Zoloft is an SSRI antidepressant and Effexor is an SNRI. They both affect the serotonin levels in the brain.

It is usually possible to go from the Zoloft to the Effexor without any problems. The other way, may cause problems (because of the effect Effexor has on norepinephrine).

But, this is a question that you should discuss with your physician. Everyone reacts to medications differently, and what is okay for one patient may not be correct for another.

Good luck.
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