M.s Getting Worse

Hi my mum and nanna both have m.S,my nanna is 65 and she is definately getting worse.In the past year her moods have been unbelievable.I feel so sorry for my grandad cos she just constantely moans at him but she really doesnt realise it.Shes paranoid,always going on about the neighbours looking into her house through the windows so she keeps the blinds shut.She moans about everything and anything and she didnt used to be like that! She needs to chill out but the doctors are rubbish and put her on medication that does nothing but if my mum goes with her to the doctors and says what shes like my nanna will say its not true when it is! My nanna is the best nanna in the whole world and I love her 2 bits but I hate the thought of her getting even worse and my grandads life been made worse! Anyone got any advice or tips at all on how to calm mood swings or anything that can help people chill or anything I would really appreciate! Love l xx