This is some data about clinical trials on homeopathic medicine and the source is:
http://www.Trusthomeopathy.Org/case/cas_cl i.Html

c l I n I c a l t r I a l s

treatment of influenza
treatment of acute childhood diarrhoea
homeopathic immunotherapy

treatment of influenza
ferley's controlled trial (ferley jp, zmirou d, d'adhemar d, balducci f. A controlled evaluation of a homoeopathic preparation in the treatment of influenza-like syndrome. British journal of clinical pharmacology 1989; 3: 329-35) looked at the effectiveness of a homeopathic preparation in the treatment of influenza and influenza-like syndromes.


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the researchers say that while a regular feature of homeopathic treatment is that two patients who have the same disease are liable not to benefit from the same treatment, there is a school of thought that certain diseases, especially some acute conditions, could be treated with substances or drug mixtures tailored to the disease characteristics alone. They add that such drugs are gaining popularity among large sections of the medical profession and also among the public who buy them over the counter.
Oscillococcinum - made of anas barbariae hepatis and cordis extractum hpus 200 c - is such a drug. The vehicle is made of lactose and saccharose and a placebo of identical appearance was made up consisting of lactose and saccharose alone. The study took place during an influenza epidemic. Patients who took part in the study were chosen from those attending gp surgeries with influenza-like syndromes, defined as a rectal temperature equal to or above 38° c or above and at least two of the following symptoms: headache, stiffness, lumbar and articular pain, shivers. Most of the participating gps were not homeopathic clinicians.
The standard treatment is five doses of oscillococcinum. The first was given at the medical practice and the patients took the remaining four on the following mornings and evenings. 237 patients received the test drug and 241 the placebo. They recorded their rectal temperature twice a day and the presence or absence of five cardinal symptoms (headache, stiffness, lumbar and articular pain, shivers) as well as cough, coryza and fatigue. Recovery was defined as a rectal temperature of less than 37.5° c and complete resolution of the cardinal symptoms.
The results showed that the proportion of patients who recovered within 48 hours of treatment was greater among the drug group than among the placebo group: 17.1% compared with 10.3% (p = 0.03).
The researchers say that the positive effect of the homeopathic preparation 'cannot be explained in our present state of knowledge' and they call for further investigation.
A repeat trial conducted by papp et al was recently published in the british homeopathic journal (1998- 87). This showed that the symptoms of patients receiving oscillococcinum were significantly milder (p = 0.023) after 48 hours than patients in the placebo group. The number of patients with no symptoms was significantly higher in the group receiving oscillococcinum from the second day onwards (verum 17.4%, placebo 6.6%) until the end of the patients' recording.


Treatment of acute childhood diarrhoea
(jacobs j, jimenez m, gloyd s et al. Treatment of acute childhood diarrhoea with homoeopathic medicine: a randomised clinical trial in nicaragua. Pediatrics 1994; 93: 719-725.)
jacobs' work set out to discover whether homeopathic treatment was useful in the treatment of acute diarrhoea in children, the leading cause of paediatric morbidity and mortality.
This randomised double-blind trial took place in two clinics in poor districts of nicaragua, a country where diarrhoea is the primary cause of mortality during the first year of life and accounts for 19% of all outpatient consultations in children aged from one to four years.
The researchers thought that acute childhood diarrhoea was an ideal condition for a homeopathic study because the short duration of illness would allow for intensive follow up, there was no standard allopathic treatment that would have to be withheld during the trial and the public health importance was great.
Eighty-one children aged between six months and five years took part. An initial history was taken for each child, a physical examination was carried out, a stool specimen obtained and a diarrhoea index score was assigned to each child. Children with type a or b dehydration were prescribed oral rehydration therapy. Those with type c were transferred to hospital and did not take part in the study.
The children were then given a homeopathic interview and examination. Information about the nature of stools, abdominal pain, vomiting, mood and temperature, degree of thirst and appetite, presence of fever, abdominal bloating, sleep disturbance, perspiration and other signs and symptoms was collected. Each child was then prescribed one homeopathic medication on an individual basis. Identical tablets without medication were used as a placebo. Follow up was daily for five days.
The treatment group had a statistically significant (p<.05) decrease in duration of diarrhoea, defined as the number of days until there were less than three unformed stools daily for two consecutive days. There was also a significant difference (p<.05) in the number of stools per day between the two groups after 72 hours of treatment.
The researchers conclude that homeopathic treatment might be useful in this condition and add that further study should be considered.



Homoeopathic immunotherapy
(reilly d, taylor ma, beattie ngm et al. Is evidence for homoeopathy reproducible? Lancet 1994; 344: 1601-1606.
Reilly d, taylor ma. Potent placebo or potency? A proposed study model with initial findings using homoeopathically prepared pollens in hay fever. British homoeopathic journal 1985; 74: 65-75.
Reilly d, taylor m, mcsharry c, aitchison t. Is homoeopathy a placebo response? Lancet 1986; 2 (8520): 881-886.)
this research was designed to answer the question: "is homeopathy a placebo response?". The results of the first two trials suggested that it was not but, because the findings were so controversial, the researchers asked independent colleagues to see if the results could be replicated in a third trial.
The three studies all used homeopathic immunotherapy in inhalant allergy as a model, the first two in hay fever and the third in asthma, with the same main outcome measure: a visual analogue score of overall symptom intensity.
Subjects were chosen from people attending an asthma outpatient clinic. Their symptoms and compliance were monitored for a four-week run-in period and they were asked not to take any new allergen-avoidance measures during the trial.
At the beginning of the run-in each patient was assessed by a homeopathic and an asthma clinic doctor. A nurse did skin tests and a respiratory physiologist measured pulmonary function and bronchial reactivity to histamine.
The study design was a randomised double-blind assessment of two parallel groups, one receiving homeopathic treatment and the other a placebo. Twenty-eight patients with allergic asthma, most of them sensitive to house-dust mite, were randomly allocated to receive either oral homeopathic immunotherapy to their principle allergen or an identical placebo. The homeopathic doctor selected the homeopathic prescription on the basis of the largest skin-test weal concordant with allergy history. The test treatments were given as a complement to patients' usual conventional care.
At the main end point four weeks after the treatment began, patients were reassessed by both doctors, diaries were checked and pulmonary function tested.
A difference in visual analogue score in favour of homeopathic immunotherapy appeared within one week of starting treatment and persisted for up to eight weeks (p=0.003). There were similar trends in respiratory function and bronchial reactivity tests.
A meta-analysis of this research and the two previous studies found a similar pattern of change: the homeopathically treated groups showed a greater improvement in visual analogue scale scores than the placebo groups. The researchers go on to ask if the explanation could be three false-positives and argue that if this were so, then the technique of randomised controlled clinical trials itself would have to be fundamentally flawed. The evidence is that either homeopathy works or that the clinical trial does not, they conclude.



M e t a - a n a l y s e s

- summaries of the three main studies

kleijnen 1991
british medical journal. 107 trials. Criteria-based meta-analysis.
 77% are positive
 the higher the scientific merit of the study, the more likely it is to show homoeopathy as superior to placebo.
 the evidence presented in this review would probably be sufficient for establishing homoeopathy as a regular treatment for certain conditions.


Overview
what is homeopathy
growth & popularity
homeopathy in the nhs
evidence for homeopathy




boissel 1996
report for european commission. 15 trials. Very strict inclusion criteria. Meta-analysis; data synthesis by combining the significance levels (p-values) for the primary outcomes from each trial.
 combined p value for the 15 trials was highly significant p=0.0002.
 ' there is evidence that homeopathic medicine is more effective than placebo' .
 little evidence of publication bias.
 further high quality studies are needed.
Linde 1997
lancet. 89 trials. Meta-analysis; data synthesis by combining the odds ratios.
 combined odds ratio 2.45 (95% ci 2.05, 2.93) in favour of homeopathy.
 odds ratio for 26 best quality studies was 1.66.
 no evidence of significant publication bias.
 the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo.
 further research is warranted.


O u t c o m e s t u d I e s

- from the nhs homeopathic hospitals
 adult and childhood asthma at the royal london homeopathic hospital
 palliative cancer care at the royal london homoeopathic hospital
 glasgow homoeopathic hospital inpatients
 outpatient care at bristol homeopathic hospital
 outpatient care at tunbridge wells homoeopathic hospital



overview
what is homeopathy
growth & popularity
homeopathy in the nhs
evidence for homeopathy



adult and childhood asthma at the royal london homoeopathic hospital
this study from rlhh followed up 24 adults and 25 children with asthma and found that 71% of the adults and 80% of the children experienced improvements in their symptoms following the homeopathic treatment. Two thirds of the adults and almost as many of the children reduced their need for inhalers and 60% of the parents of the children reported a decrease in the need to consult their gp for urgent asthma treatments.


Palliative cancer care at the royal london homoeopathic hospital
a study of 50 consecutive patients with cancer who were attending the rlhh complementary therapy cancer clinic was performed. Three quarters of these patients had spread or recurrence of their cancers before being referred to the clinic. Standard questionnaires showed statistically significant improvements in anxiety/depression and physical symptoms of these patients after treatment.



Glasgow homoeopathic hospital inpatients
100 sequential inpatients in glasgow homoeopathic hospital showed that when assessed three months after discharge 58% had significant improvements in their main complaint and 67% had similar improvements in mood and well-being. Significant was assessed as being rated by the patient as "of value in daily living".
In terms of the impact of ghh in-patient care on conventional care and costs, 72% patients reported fewer admissions to other hospitals; 51% fewer attendances as out-patients for conventional treatment; 40% fewer visits to their gp and 46% a decrease in their use of conventional medicines.



Outpatient care at bristol homeopathic hospital
a study of 2000 patients attending bhh in a 12 month period from november 1997 showed overall that three quarters of the patients achieved what they described as "moderately better" or "much better".



Outpatient care at tunbridge wells homoeopathic hospital
a study of 1372 patients who had attended outpatients at twhh showed that overall improvement was reported in over three quarters of the patients with patients with certain conditions being most likely to have received benefit - relief of anxiety/depression or flushes in women with breast cancer being the greatest.
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replied July 2nd, 2004
Experienced User
I Appreciate the Effort!!!!!!!
Certainly you made a stab at proving homeopathy and cited many antiquated studies which have not been borne out by further testing. All the latter studies you cite have no validity since they are not controlled. I will not attempt to pick apart every one of the studies you mention, but will demonstrate the fallacies of homeopathy by examining the first:
the criteria and clinical course of influenza are as follows according to the cdc: symptoms of influenza may include quick onset of high fever, chills, dry cough, headache, runny nose, sore throat, fatigue and myalgia (general muscle achiness). These symptoms usually last from two to five days, unless complications develop. The study you cite does not include high fever as a criteria since any fever, even minimal will do just fine for the study you cite. Also note symptoms last 2-5 days. This means by the end of the study period in the study you cite, the illness could be over with or without treatment.
The atopy studies are interesting but have since been disproven.
I will give you the diarrhea study. I don't know how you do it, but I will concede that homeopathy is good for treating excessive poop.
Thanks for at least trying to present a balanced argument. We will have to agree to disagree on whether your specialty or what you do as a living has any merit, but certainly I respect you as an individual for defending your statements with some scientific studies. So no more india statements or jungle jokes from me. Thanks!!!!
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replied July 3rd, 2004
Experienced User
"excessive Poop"
Quote of previous message:

"i don't know how you do it, but I will concede that homeopathy is good for treating excessive poop".

We are almost there. Atleast now you concede homeopathic medicine helps for something apart from the psychological plane.

I am sure one will recognise it helps for other ailments too.

I am working with a nephrologist on a subject of how much homeopathic medicine will help in reducing the need for dialysis in patients of chronic renal failure especially in people who are unable to undergo kidney transplant due to other medical complications. Though your field of interest is orthopaedic surgery, I am sure you will this of some interest.

Dr.Venugopal gouri.
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replied July 3rd, 2004
Experienced User
Double Blind Study
You do a double blind study on the subject and I will help you get it published.
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replied July 3rd, 2004
Experienced User
Sure,
thank you.
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replied July 3rd, 2004
Experienced User
Journals
When trying to introduce scientific literature to a larger audience, it is better to publish in the better known journals such as jama, nejm, lancet, etc. The specialty journals such as nephrology may also be an appropriate publication journal. If the goal is to educate the public and the greater medical community about the scientifically proven merits of homeopathy, then it would be wise to avoid publication in eccentric journals such as homeopathy or journal of alternative medicine.
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