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Anxiety after Acetometaphin / Paracetemol / Tylenol overdose

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a friend of mine accidentally overdosed on acetometaphin/Tylenol and has developed anxiety, which has not occurred prior to this. is this a short term affect caused by the overdose or is this a long term affect that needs more attention

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replied December 14th, 2007
Anxiety and Stress Answer A3457
Tylenol ("acetaminophen" or "paracetamol") is a common and largely used medication for pain and increased temperature. Toxic doses of Tylenol are around 150-200 mg/kg body mass. Toxic doses damage the liver and kidneys.

Individuals who have overdosed on paracetamol generally display no specific symptoms for the first 24 hours. Although nausea, vomiting, and diaphoresis may occur initially, these symptoms generally resolve after several hours. After resolution of these symptoms, individuals tend to feel better, and may believe that the worst is over. If a toxic dose was absorbed, however, the individual develops overt hepatic failure after this brief feeling of relative wellness. For massive overdoses, coma and metabolic acidosis may occur prior to hepatic failure.

Damage generally occurs in the liver as it metabolizes the paracetamol. Rarely, acute renal failure also may occur. This is usually caused by either hepatorenal syndrome or Multiple organ dysfunction syndrome. Acute renal failure may also be the primary clinical manifestation of toxicity. In these cases, it has been suggested that the toxic metabolite is produced more in the kidneys than in the liver.

There is no data that indicates that an overdose of paracetamol can cause anxiety. Anxiety is probably not due to the Paracetamol itself but could be due to some kind of post-traumatic reaction. Trauma, in this case,probably is the poisoning with paracetamol.

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