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spotting after taking Metformin - PCOS?

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Curious if spotting after taking Metformin could be used for diagnosis of PCOS? I've always been somewhat overweight, I have a hx of hirsutism, rare menese, and an ovarian cyst. Lab tests always normal - no dx of PCOS given.

During college and grad school (2008) my weight reached 223. I lost 45 lbs over 3 years with diet and exercise. At 180 I couldn't loose more weight, went to see PA @ 178 lbs, she prescribed phentermine 30 and then 37.5 mg the month following. In two months lost 1 - 2lbs despite phyiscal activity (Cardio at least 5x/week for 45 minutes and weights 2x/week for 30 mins - often would do 2 cardio workouts a day) and only eating 1200 - 1500 calories per day.

I asked to start Metformin as a trial in addition to phentermine. started metformin 500mg qd - have lost 5.8 lbs in 2 weeks, at day 4 or 5 of metformin therapy started spotting which developed into a menses, despite being on week 2 in oral contraceptive? Could this menses be used as a diagnostic tool for PCOS

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replied April 4th, 2012
Ovulation and Ovaries Answer A33528
Welcome to ehealthforum,
PCOS can be diagnosed with help of hormonal analysis results along with ultrasound scan results correlated with your symptoms and examination findings. PCOS is most commonly caused due to insulin resistance, hence use of insulin modifiers can result in better response. If ovulation results, you can experience midcycle bleeding. Visit your doctor/gynecologist for further evaluation and assistance. Combining weight loss regime and exercise pattern along with treatment of PCOS will help in weight reduction along with control of other symptoms. Be in regular monitoring and follow-up with your treating doctor/gynecologist and report any new/abnormal symptoms immediately. Drink plenty of water. Take adequate rest. Maintain healthy diet and lifestyle.
Take care.

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