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i have 50% sickle cells 50%normal cells what would be the prognosis on my health i have a sickle cell crisis once in a year or two


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replied April 17th, 2008
Inflammatory and Abnormal Cell Disorders Answer A3939
Sickle-cell disease is a genetic disorder where erythrocytes contain defective hemoglobin (HbS). Because of the sickle form of the erythrocytes they can stick in the capillaries of various organs (brain, lungs, spleen, kidneys, bones…) causing infarcts and organ damage. Sickle erythrocytes live shorter life spans than normal erythrocytes which leads to hemolytic anemia. Spleen damage makes such patients more vulnerable to various bacterial infections. Prognosis of the disease depends not only from occurrence rate of the crises but also from the type of crises (vaso-oclusive, hemolytic, aplastic, splenic…) and which organs are affected.


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