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Propylthiouracil use during pregnancy

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When did I concieve? Least period 10/25/08
Is taking PTU while I'm pregnant okay?

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replied December 4th, 2008
General Q and A Answer A5041
Current medical status: hyperthyroid
Current medical treatment: PTU (10 Tablets)

Assuming that the normal length of your menstrual cycle is always 28 days, you might have conceived if an intercourse happened on 08 november.

Propylthiouracil causes mild hypothyroidism when the drug is used close to term. Use of PTU early in pregnancy does not produce fetal goiter because the fetal thyroid does not begin hormone production until approximately the 11th or 12th week of gestation.

However, there are studies in which congenital anomalies have been reported in newborns exposed to propylthiouracil in utero. The data is not sufficient to determine the significance, because other medications were taken and other medical conditions were present in the patients.

When compared to other drugs given for hyperthyroidism, propylthiouracil shows lowest levels of transplacental passage and is considered the drug of choice for the medical treatment of hyperthyroidism during pregnancy. If the medication has to be taken, the usage should be under strict supervision by an endocrinologist and gynecologist.

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