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Preventing miscarriage

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I have MTHFR and Factor V. I just found out that I'm 6 wks pregnant. I'm currently taking lovonox (1 per day) and prometrium (3x per day) and a normal prenatal vitamin. I've lost 4 pregnancies already and am only 25. I'd love to be able to give birth to a child one day (preferably this pregnancy)... are there any additional things I can be doing to make my chances greater? I would prefer to be as non-invasive as possible this time around as I've felt that in the past the vaginal ultrasounds haven't helped me to sustain my previous pregnancies. I'm appreciative of your assistance and advice.

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replied June 5th, 2010
Complications during Pregnancy Answer A12876

Welcome to the ehealthforum. I am glad to help you out. You have got 2 different problems but unfortunately both of them are known to produce pregnancy losses. Factor V leiden is known to increase the propensity of deep vein thrombosis and also causes thrombosis (clots) in the placental circulation resulting in a miscarriage.

The treatment consists of givng LMW heparin (lovenox) along with aspirin. MTHFR is known to result in hyperhomocystenemia as homocysteine is not able to concert to methionine in the absence of this enzyme. Increased homocysteine levels are known to cause increased blood pressure (pre-eclampsia and thus miscarriage. There are also increased chances of congenital abnormalities in the growing foetus like Down’s syndrome. The treatment consists of giving folic acid supplementation throughout the pregnancy.

I sincerely hope this information helps. Take care.

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