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Possible side effects of prednisone

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my sister has Lupus SLE, advised wysolone 20mg, but takes 15mg,
as she has fear it has side effects on her kidney? she also has high level of protien in her body, and is advised low protien diet food.
I want to know all possible side effects of wysolone.
Awaiting your reply.

Kind regards,

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replied December 19th, 2009
General Q and A Answer A8593
Hi, welcome to the ehealth forum and I am glad to help you.
You seem to be concerned about the possible side effects of wysolone(prednisone) which belongs to class of drugs called as corticosteroids.
Treatments with corticosteroids for short duration (lower than one week), even at high doses, have few adverse effects.The risk of adverse effects grows with treatment duration and increase in the dosage. Various disorders can be observed:
• Cushing’s habitus characterised by lipid redistribution with rounded face,narrow mouth,supraclavicular hump,obesity of trunk with relatively thin limbs.
• Edema and fluid retention (to be prevented by a diet low in sodium), hypokalemia, increase in blood pressure, aggravation of diabetes, atrophies, muscular weakness, fatigability, menstrual cycle disturbances, growth retardation in children.
• Adrenal insufficiency at withdrawal of the treatment, which occurs even in neonates when the mother was treated during pregnancy due to suppression of hypothalamic pituitary axis. The discontinuation of the treatment can also induce various symptoms: fever, myalgias, arthralgias.
• Bone disorders: development of osteoporosis which can be attenuated by the maintenance of exercice, calcium and vitamin D supplementation, a hormonal substitutive treatment after menopause or by a bisphosphonate treatment. In addition, osteonecrosis of the femoral head can be exceptionally observed.
• Neuropsychiatric disorders with various symptoms like nervousness, insomnia, depression, aggravation of epilepsy, increase in intracranial pressure in children.
• Ocular disorders after local and general administration such as glaucoma, cataract etc.
• Hematologic modifications: increase of leukocytes and thrombocytes, decrease of T lymphocytes .
• Digestive disorders, peptic ulcer with an atypical symptomatology and cause of bleedings, associated with silent perforation of ulcers.
• Infections: increase in the risk of infections, bacterial (tuberculosis) or viral (chicken pox, herpes zoster herpes), or mycotic (candidiasis). The infection generally evolves with low noise, without fever. The vaccination of people treated by corticoids is disadvised, especially with live vaccines.
• Growth retardation: administered to children, long term administration to children can induce growth retardation requiring treatment with growth hormone.
• Exceptionally shock may occur during their administration by intravenous route.
Drug interactions are possible: the drugs which are enzymatic inducers by accelerating the degradation of corticosteroids can reduce their efficacy.
The risk of adverse effects of certain antiarrhythmic drugs, cardiac glycosides, anticoagulants, is increased in patients treated by corticoids, probably because of hypokalemia. The prescription of a corticosteroid to a diabetic can worsen his diabetes and decrease insulin efficacy.
Hope this helps. Take care.

Note: This information is not for making any diagnosis and not to make any doctor-patient relationship and not to replace any existing one.

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