Hi, my father was diagnosed with Parkinson's disease in August of this year. The main and only visible symptom is his left hand tremor. He was initially prescribed with Sinemet (Levodopa and Carbidopa) one tablet, three times a day. This didn’t really help much with his tremor and it actually affected his moods - he has become ‘numb’ and not feeling happy like he used to be (I should note that my dad has been on antidepressants for years and the neurologist told him that the 2 medications will not conflict with each other). So after trialling it for 6 weeks, he went back to his neurologist and has been increased to 2 tablets, 3 times a day. His shaking is still there (although there are periods when it is shaking less but shaking still) and his mood has decreased again. The neurologist has told him to wait 8 weeks to see how he goes with the new dose. I need help as my dad was happy and a different person before this medication. Has this happened to anyone else? Are there any other medications that might work if Sinemet does not? We don’t know where else to turn.
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replied October 20th, 2017
Thank you for asking at Ehealth forum!

I read your question and i understand your concern. Mood changes to depression and expressionless facies is a symptom very common in parkinson's. Dose and medications need to be adjusted if the tremors are not relieving. Wait in there and observe. Gradual increment of dose is considered.

I hope it helps. Stay in touch with your healthcare provider for further guidance as our answers are just for education and counselling purposes and cannot be an alternative to actual visit to a doctor.
Take care

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