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I remember the date it began. It was November 20, 2008. For over a year I have been struggling to diagnose what is wrong with me. I originally thought my problem was sleep related. I have no trouble getting to sleep but often wake up in middle of the night. I usually always get a good 7-8 hours of sleep but find it very hard to get any sleep after 8am. Regardless of how much sleep I get I NEVER FEEL REFRESHED. I have had not one but 2 sleep studies done. The first doc said I had very mild sleep apnea when sleeping on my back. I then went to a neurologist who was highly reccomended and she gave me another sleep study that also tested for Narcolepsy. She said sleep apnea was non existent and no narcolepsy. So then I am tested for a thyroid problem, anemia and these tests come back negative. I get a full physical and get my liver tested and nothing is found. I have considered getting a brain scan but never have any headaches and have already spent so much money. In 2008 I stopped taking adderral which I had been addicted to for several years. Recently I tried going on a lower dosage of this medication to se if my problems were caused by not having adderral anymore. From now on when I take adderral all it does is makes me cracked out. I dont feel focused or any more refreshed. Provigil also does nothing to give me energy. I workout five days a week, have a great diet etc. and still feel like im living my days without sleep. My problem is extremely bizarre. I have considered me having depression. i have never felt real depressed but have many of the symptoms and have had several docs tell me im depressed. I took Lexapro for 2 weeks and during the first two weeks I felt normal! After the first two weeks though I felt horrible again. I tried Cymbalta and it gave me nothing but insomnia. I have tried Wellbutrin 3 times both immediate and extended release and it did nothing. I just finished a 6 eek trial of Zoloft and nothing. I have now pretty much given up on antidepressants and am thinking my problem is not depression like my docs think. I should also mention that I am not a heavy drinker but drink on weekends sometime and alcohol has no buzz for me anymore. All I feel when drinking is more tired than I already am. As for coffee I continue drinking it every morning but dont know why because it does NOTHING for me. If anyone has any idea what is going on with me I will be eternally grateful. Im very desperate.
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replied December 1st, 2009
Extremely eHealthy
I know the second doctor didn't see it, but did the first doctor try anything for your sleep apnea? Like a CPAP machine or an oral appliance?

Do you feel like this all the time? Are there ever days when you feel normal? If there are days when you feel normal, maybe this could be bipolar disorder, rather than depression. Has anyone mentioned the possibility of Chronic Fatigue Syndrome? Do you have any other symptoms, like muscle or joint pain, sore throat, loss of memory, etc? Those could be symptoms of CFS.

You said you remember the exact date when it started. Did anything else change around that time? Change in job, diet, major life event, illness, anything?

I know they checked your thyroid, but maybe you have some other similar issue going on. Perhaps going to an Endocrinologist would help. If your thyroid levels are on the low or high side of normal, perhaps that's not normal for you and you might need medication for that.

I think it would also be a good idea to cut out all caffeine, alcohol, drugs (that aren't specifically prescribed) or anything else like that. If you say they don't do anything for you anyway, why do you continue to take them? Some of it may actually be doing more harm than good.

I wish I could help you more, but I really do think that if you are sure that you don't have Bipolar disorder or Chronic Fatigue Syndrome, going to an Endocrinologist may be a good next step. Best of luck to you. If you get more information or anything, feel free to re-post.
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replied December 1st, 2009
Thanks for the reply and I am definitely going to consider seeing a endocrinologist. The first sleep doctor suggested I use some sleep cushion that prevents me from sleeping on my back. The second doctor said apnea wasn't my problem and suggested doing oriental yoga which did nothing. I should mention that the second doctor was a neurologist/sleep specialist. The first was a sleep specialist focusing on the lungs. I am extremely fit so was concerned when I was told I had mild sleep apnea so I had another study done.

I have spent much time researching CFS but I never have a sore throat and have no muscle pain. I always feel fatigued every day so don't think i'm bipolar.

I started waking up unrefreshed the day after stopping wellbutrin. I had been prescribed wellbutrin to help with getting off adderral. After 3 weeks I quit it after not noticing a difference. The day after stopping wellbutrin I went back on adderral at the lower dosage. This is the day when the fatigue started. After weeks of unrefreshing sleep my doctor upped my adderal dosage. When this didn't work I quit adderal and went the depression route. I tried Lexapro, cymbalta, strattera, provigil, wellbutrin again. After this I took 3-4 months off all medication. Then in September I gave wellbutrin another try. Still did not help. Then zoloft for 6 weeks and nothing. It has been a long journey. Thanks for your help!
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replied December 10th, 2009
Hello RTHill1982,
Good day! How are you? Hope you have some improvement..
I don't know whether it will help you or not. But, I think, you have to try it. Its a gadget or device which known as eMIND or mcsquare.
Its using neurotechnology which will help us to boost our concentration, reduce our stress and help us to have a deep sleep.I have 1 and it really works.
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replied January 14th, 2013
Please email where to buy device, I'm in the USA
Where can I purchase either one of these devices. I been a long time sleep disorder sufferer and would love to feel refreshed again + concentrate when I need to. How much are they? Please email me info.
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replied January 4th, 2013
Sleep problems - one solution
I have suffered from difficulties getting to sleep and also not feeling refreshed upon waking for more than 25 years. I tried so many things over the years to fix this problem and everything failed. I recently was diagnosed with depression and was prescribed MIRTAZAPINE 15mg, 1 tablet before bed. The doctor said it would help with my sleep problems, and it has. I now fall asleep within 10 minutes and sleep throughout the night without waking. I also wake up feeling very very good. THIS HAS CHANGED MY LIFE. Hopefully this post can help others.
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replied January 4th, 2013
The Link Between Depression and Not Feeling Refreshed After Slee
Depressed people spend less time in the REM (Rapid Eye Movement) stage of sleep, which causes them to feel unrefreshed when they wake up.
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replied April 1st, 2013
Unrefreshed sleep
You may have no R.E.M. and slow wave sleep because it was suppressed by meds. Look up acetylcholine. You can stimulate AcH supposedly by taking gingko biloba and Vit. B complex, and lecithin. If your brain doesn't have enough AcH, your memory will be affected. The doctor to see for that would be a specialist in aging or Alzheimers. They know about acetylcholine. Also, if you have your face in a computer a lot, get a low blue light filter for it, as the blue light in computer screens suppresses melatonin. Also try taking melatonin. I am going through hell because of this problem of unrefreshed sleep and to complicate it, I have Bipolar I.
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replied May 21st, 2013
I just wanted to tell the original poster that I am under going the exact same things and is been about five years. I went to all the same doctors and none knew what was wrong with me. To this day I have no clue. But, I do know that I can't function I can't goon like this. Please help someone
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replied May 21st, 2013
I just wanted to tell the original poster that I am under going the exact same things and is been about five years. I went to all the same doctors and none knew what was wrong with me. To this day I have no clue. But, I do know that I can't function I can't goon like this. Please help someone
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replied August 11th, 2013
Omg, same here. Late 40s female. Non-refreshing sleep for past 5 years. No DTR has found out why. Just take variety of stimulants that don't help much. Plz post when u find out why, as will I. I had bad virus 5 years ago but no DTR finds significance. Ugh!
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replied August 29th, 2013
No Refreshing/Restorative Sleep for Me, Either
Me too, since July 11, 1976. Started with a dizzy spell and heart palpitations, which I interpreted as a heart attack, recalling the my father had dropped dead with one at age 32. Because of this, I then had a panic attack, which stuck with me like glue. This was in a noisy and dangerous industrial environment, in which I had a couple of seriously close calls. GAD interspersed with panics ensued, and I developed psychological problems. These were pretty well put into remission not by medical intervention, but with one self-help book, "Hope and Help for Your Nerves," by Claire Weeks. I then understood what was going on, so it was easy to learn to ignore it.

Those first panic attacks continued for a couple of days, so I went to an ER. The Doc said it was "just nerves," and that I should see a PsychDoc. I've travelled along that path ever since. One thing I have learned is that one you get labeled with a disease that can't be objectively diagnosed, it's nearly impossible to get rid of the Dx, so that you can move on to other treatments.

I've had a few 106+ fevers from strep infections, with one nearly killing me when I was 3. I did have one in combination with the flu about 7/11/76. Bicillin is my friend, when I can find it. 4 hours, and the fever's broken. If I have to go the pill route, it's high fever for 3-4 days, and 2 weeks to shake the malaise.

I've been told I have depression for so long that it's depressing. No tri-cycs or SSRIs, anti-seizures, benzos, opiates, etc. have produced one single night of refreshing/restorative sleep. Nothing but side effects. Rozerem helps me get to sleep with very few exceptions, but the sleep is still not refreshing/restorative.

To me, it has always seemed more like PTSD, maybe from the initial scare plus major work stress, but since the treatment isn't much different, the only reason to sort it out is to rule in/out genetic v. environmental causation inorder to help my kids.

When I explain these things to medical professionals, they just become glassy-eyed. That would be 30+ medical professionals.

Any ideas?
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