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"The immediate therapeutic implication is that maintenance laxatives are disease-modifying in PD. "

Quantifying rigidity of Parkinson's disease in relation to laxative treatment: a service evaluation

Br J Clin Pharmacol. 2016 Aug;82(2):441-50. doi: 10.1111/bcp.12967. Epub 2016 May 21.

Facts-

Bad belly-especially constipation-worse PD symptoms
Multiple reports of antibiotics resulting in worsening PD symptoms-often irreversible

Study-
Retrospective Study- London- 79 patients- very strong association between beginning laxatives-- first fiber or osmotic (eg Miralex) -if not effective novel agents-- both approved in UK-Prucalopride (Resolor) and more recently Linaclotide-US too- (Linzess) stopped the progression of extensor rigidity over time!!

Also validated- courses of antibiotics worsens PD rigidity-often irreversible
My Conclusions ( MD with PD- not a neurologist)--ask your PMD-
1) if you are constipated-make sure you treat it effectively
2) take antibiotics only when necessary
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replied August 23rd, 2016
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