Medical Questions > Womens Health > Menopause Forum

My wife's menopause at 33

Hi All,

I’m joining here because I (33, male) am concerned about my wife (also 33).

She was recently diagnosed with premature menopause which was of course quite a blow for her and us (in particular in relation to our family plans).

She’s started HRT 2 weeks ago (the day when the news were released that HRT causes higher rates of ovarian cancer; again not great).

I’m concerned because we presumed that typical phenomena of menopause would get better with HRT: in particular mood imbalances. But the opposite seems to be the case: she’s totally bogged down, unmotivated to exercise (though she is normally going to the gym every day enthusiastically) and says she’s mildly aggressive at work. She just seems totally absent-minded and sad when we are together.

Is that just early signs of HRT and nothing to worry about yet?

Thanks PR
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replied March 26th, 2015
Active User, very eHealthy
I am sorry your wife has been diagnosed with premature menopause. Hopefully, a thyroid or pituitary abnormality was ruled out as being the cause because any endocrine problem can disrupt ovarian function. And fixing the underlying problem can restore normal ovarian function.

HRT is a very individual thing. It can take a bit of trial and error to find the right "fit" for any one woman. Being that she is so young, birth control pills are also an option. So don't hesitate to try other options whether it be patches, pills, or gels and various dosages. She will just need to be sure to take progesterone or a progestin with the estrogen (as a combined HRT or separate meds) to protect her uterine lining from the proliferative effects of estrogen.

As far as the increased risk of ovarian cancer with HRT, that incremental risk is so small, I am surprised it even made the "news." According to this February 2015 article http://www.nlm.nih.gov/medlineplus/news/fu llstory_150918.html "for women who take hormone therapy for five years from around age 50, one extra ovarian cancer diagnosis for every 1,000 users would be expected, and one extra ovarian cancer death for every 1,700 users, the study found."

Normally for women in early menopause, the benefits of HRT outweigh the risks because the loss of ovarian function or removal of ovaries increases risk for a number of health problems, the top two being heart disease and osteoporosis, two big killers of women.

Kudos to you for posting here in an attempt to help your wife. I hope she finds the right HRT to get back to normal! Keep us posted.
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replied April 3rd, 2015
Active User, very eHealthy
Try to ask about natural remedies for menopause symptoms, wc have less side effects I hear. I never really took HRT but read about those mood imbalances.
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replied April 3rd, 2015
Community Volunteer
Hi PaulRa: HRT does take time to work...I have used this for thirty years and it does help...If she is still concerned have her talk to OB/GYN to see what he/she suggests...Take care...

Caroline...
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