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I was diagnosed with mild SLE 3 yrs ago. I take plaquenil for this. I stopped taking microgygnon nearly 5 months ago and have had fairly regular (although extremely light) periods since. My partner and I are trying to concieve but have had no luck yet. I know that SLE can affect pregnancy but does it cause problems with conception? I know that getting pregnant can take a while but I didnt want to go through a year of trying to find out I could of done something to help?

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replied March 7th, 2010
Lupus Answer A10486
Hi, welcome to the ehealth forum and I am glad to help you.
You seem concerned about SLE interfering with conception.
SLE does not interfere with conception, and there is no increase in flares during pregnancy. However, there are increased rates of spontaneous abortion, prematurity and intrauterine death. Plaquenil can be continued safely during pregnancy so that stopping the drug may not flare up lupus and endanger the pregnancy. You may consult your doctor if there are other reasons that may be delaying the conception.
I would NOT recommend an oestrogen containing (combined) pill e.g. Microgyon unless anti-phospholipid antibodies, as measured by the anti-cardiolipin antibody AND "lupus anticoagulant" tests, have been done and are both negative. I would have the tests repeated 3-6 months after starting the combined pill if it is taken. Low platelets can be the first sign of anti-phospholipid syndrome (sticky blood) which causes blood clots (thrombosis). As the oestrogen containing (combined) pill can also increase the risk of blood clots (thrombosis), this form of contraception can be very dangerous in people with anti-phospholipid antibodies, as measured by the anti-cardiolipin antibody OR lupus anticoagulant tests.
The oral contraceptive pill should not be prescribed without discussion with the hospital specialist, as oestrogens may exacerbate lupus.
Hope this helps. Take care.
Note: This post is not to emphasise final diagnosis as the same cannot be made online and is aimed just to provide medical information and no treatment suggested above be taken without face to face consultation with health care professional.

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