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Lamotrigine and chronic kidney disease

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I have stage 3 ckd. I take Lamictal for a mood disorder and was wondering if it is harmful to the kidneys? Also, what about protein and phosphorus? I understand there is some controversy about protein being harmful. Thank you!


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replied September 14th, 2009
Kidney Conditions Answer A7230


Lamotrigine (brand name: Lamictal) is metabolized mainly by glucuronic acid conjugation, with the majority of the metabolites being recovered in the urine. In a small study comparing a single dose of lamotrigine in patients with varying degrees of renal impairment with healthy volunteers, the plasma half-life of lamotrigine was significantly longer in the patients with renal impairment. Therefore, the dosage of lamotrigine should be adjusted according to the level of kidney failure. The lamotrigine itself, is not reported to affect the function of the kidneys.


Studies have been conducted that conclude that a moderate dietary restriction of protein and phosphorus is an acceptable and effective regimen for delaying progression of functional deterioration in early renal failure.


You might want to visit a nephrologist for additional information about the effects of lamotrigine, proteins, and phosphorus on kidneys that are already in chronic kidney disease stage 3.


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