Medical Questions > Conditions and Diseases > Kidney Conditions Forum

Lamotrigine and chronic kidney disease

User Profile
I have stage 3 ckd. I take Lamictal for a mood disorder and was wondering if it is harmful to the kidneys? Also, what about protein and phosphorus? I understand there is some controversy about protein being harmful. Thank you!

Did you find this post helpful?
First Helper User Profile

User Profile
replied September 14th, 2009
Kidney Conditions Answer A7230

Lamotrigine (brand name: Lamictal) is metabolized mainly by glucuronic acid conjugation, with the majority of the metabolites being recovered in the urine. In a small study comparing a single dose of lamotrigine in patients with varying degrees of renal impairment with healthy volunteers, the plasma half-life of lamotrigine was significantly longer in the patients with renal impairment. Therefore, the dosage of lamotrigine should be adjusted according to the level of kidney failure. The lamotrigine itself, is not reported to affect the function of the kidneys.

Studies have been conducted that conclude that a moderate dietary restriction of protein and phosphorus is an acceptable and effective regimen for delaying progression of functional deterioration in early renal failure.

You might want to visit a nephrologist for additional information about the effects of lamotrigine, proteins, and phosphorus on kidneys that are already in chronic kidney disease stage 3.

Did you find this post helpful?
This question has been answered by the doctor. This topic is now open for public discussion, however no comments below this point will be answered by a doctor.
Must Read
The kidneys filter blood and regulate body flood. What happens during kidney failure? And what types of kidney failure do doctors diagnose?...
There are three main condition which cause renal (kidney) failure. Learn what causes kidney failure and what factors increase your risk of kidney problems....
What are the signs of acute or chronic kidney failure? Which ones are more serious than others? And when should you ask a doctor or go to the ER for help?...
DISCLAIMER: "Ask a Doctor" questions are answered by certified physicians and other medical professionals. For more information about experts participating in the "Ask a Doctor" Network, please visit our medical experts page. You may also visit our Kidney Conditions , for moderated patient to patient support and information.

The information provided on eHealth Forum is designed to improve, not replace, the relationship between a patient and his/her own physician. Personal consultation(s) with a qualified medical professional is the proper means for diagnosing any medical condition.