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Increased value of Nse tumor marker

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Hello, the question is about a man 39 years old, serious smoker. He has cough ( more atypical than before of my opinion) and incereaed value of NSE tumor marker in the profilactic measurements of all the tumors markers
Nse value- 19.46 ng/ml in refer. Values < 16.3
Other tumor markers are as following;
Total Psa - 1.09 ng/ml in ref. Values < 4.00
AFP - 1.5 ngml in ref. Values < 8.78
Ca72-4 - 1.05 u/ml in ref. Values < 6.0
Cyfra 21-1 - 2.19 ng/ml in ref.values < 7.7
Cea- 1.81 ng/ml in ref . Values< 5.00 for non-smokers and < 10.00 for smokers
CA 19-9 - 4.66 u/ml in ref. Values < 37

My question does the High Nse value shows that there is lung cancer ?
Thank you
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replied September 29th, 2018
Thank you for asking at Ehealth forum!

I read your question and I understand your concern.
Although its a good tumor marker but its sensitivity is only 60% and specificity is also low.
Clinical correlation and other investigations specifically biopsy will help in digging out the problem.
I hope it helps. Stay in touch with your healthcare provider for further guidance as our answers are just for education and counselling purposes and cannot be an alternative to actual visit to a doctor.
Take care
Khan
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