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fever - shivering, sweating, throat pain muscle & joint ache

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My wife has fever and rash now for over one month. It started with flu-like higher fever - shivering, sweating, throat pain muscle & joint aches and pain. From sixth day she started having rashes. After 10 days she was admitted in hospital. She has been given antibiotic through vain for nearly 10 days. Then all type of pains in throat, muscle, joint has gone. But she still has fever and rash. Doctors have run many many test - blood tests, CT Scan, X-ray, Ultra sound. All negative. They have ruled out any cancer thing. Getting anxious with this unexplained fever. Now her fever ranges between 99 to 101 occasionally 102. Doctors have no answer. We are worried. (She has iron deficiency and takes iron infusion twice an year for last three years. This is only iron deficiency. there is no related disease)

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replied April 23rd, 2014
Cold, Flu and Viral Infections Answer A46834
Thank you for asking!
I suppose your wife is having a PUO / Pyrexia of unknown origin.Fever of unknown origin (FUO) was defined in 1961 by Petersdorf and Beeson as the following: (1) a temperature greater than 38.3C (101F) on several occasions, (2) more than 3 weeks' duration of illness, and (3) failure to reach a diagnosis despite 1 week of inpatient investigation.
Patients with undiagnosed FUO (5-15% of cases) generally have a benign long-term course, especially when the fever is not accompanied by substantial weight loss or other signs of a serious underlying disease. so no worries.So hang in there. there is a long list of possibilities which doctors will rule out by exclusion criteria .Let me give you some of the list
Abdominal Abscess
Acute Lymphoblastic Leukemia
Acute Myelogenous Leukemia
Adrenal Carcinoma
Adrenal Insufficiency
Amebic Hepatic Abscesses
Atrial Myxoma
Atypical Mycobacterial Infection
Bacillary Angiomatosis
Bacteroides Infection
Brain Abscess
California Encephalitis
Campylobacter Infections
Carcinoid Tumor, Intestinal
C burnetii infection
Chagas Disease (American Trypanosomiasis)
Chronic Bacterial Prostatitis
Chronic Lymphocytic Leukemia
Chronic Mesenteric Ischemia
Chronic Myelogenous Leukemia
Clostridial necrotizing fasciitis
Colon Cancer, Adenocarcinoma
Cytomegalovirus Colitis
Dengue Fever
Diabetic Ulcers
Drug Fever
Eastern Equine Encephalitis
Emphysematous Pyelonephritis
Empyema, Gallbladder
Empyema, Pleuropulmonary
Eosinophilic Pneumonia
Eosinophilic Toxocariasis
Epididymal Tuberculosis
Epidural Abscess
Erythema Multiforme (Stevens-Johnson Syndrome)
Factitious Fever
Gallbladder Gangrene
Gastroenteritis, Viral
Graves Disease
Hairy Cell Leukemia
Hepatitis A-E
Herpes Simplex
Human Immunodeficiency Virus
Human Herpesvirus Type 6
Hypersensitivity Pneumonitis
Inflammatory Bowel Disease
Intra-abdominal Sepsis
Japanese Encephalitis
Kikuchi Disease
Legionnaires Disease
Leukocytoclastic Vasculitis
Libman-Sacks Endocarditis
Listeria Monocytogenes
Liver Abscess
Lung Abscess
Lymphocytic Choriomeningitis
Lyssavirus Infection
Malassezia furfur Infection
Malignant histiocytosis
Mastocytosis, Systemic
Mediterranean Fever, Familial
Mediterranean Spotted Fever
Miliary Tuberculosis
Mycoplasma Infections
Naegleria Infection
Neuroleptic Malignant Syndrome
Nonarticular Rheumatism/Regional Pain Syndrome
Nonbacterial Prostatitis
Norwalk Virus
Pancreatitis, Acute
Pelvic Inflammatory Disease
Pharyngitis, Viral
Pneumonia, Viral
Prostatic Abscess
Q Fever
Rat-bite Fever (S minor)
Rhinocerebral Phycomycosis
Sphenoid Sinusitis
Trypanosoma Infection
Differential Diagnoses
Catscratch Disease
Celiac Sprue
Graft Versus Host Disease
Pericarditis, Acute
Pericarditis, Constrictive
I hope you see it in a right perspective.Your doctors are doing fine.
It will take time. Let them handle it. Your wife will be fine as soon as the underlying cause is identified.
Take care

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