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I recently had eleveated LFTs(109 ALT, 60 AST)and repeated 3 weeks later 105 ALT, 58 AST. Hep panel w/reflex norm, all other lab work normal. I am overweight but not obese (30% body fat approx), and am otherwise healthy, my do ordered an abdominal ultrasound. I have hx of chronic diahreea for 4 yrs. Gastro did full, to include all possible lab tests and EGD etc, work up on me 2 yrs ago and found nothing.

What could this be? Any possibility the two could be related? If so what do you think?


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replied October 28th, 2009
Liver Disorders, Hepatitis A,B,C Answer A7663
Hello and welcome to eHealth Forum!

Many a times AST and ALT (both are collectively called transaminases) rise ((109 ALT, 60 AST)and repeated 3 weeks later 105 ALT, 58 AST) without any cause. Because AST is found in many other organs besides the liver, including the kidneys, the muscles, and the heart, having a high level of AST does not always (but often does) indicate that there is a liver problem. For example, even vigorous exercise may elevate AST levels in the body. However to reach at that conclusion the medical causes of these raised transaminases have to be ruled out.

Causes of liver transaminase elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. Steatosis and cirrhosis are ruled out by the ultrasound. Other common health conditions, such as diabetes, heart disease, pancreatitis, hemolytic anemia and thyroid disease, can also cause liver transaminase elevations.

Most liver diseases are characterized by greater ALT elevations than AST elevations except cirrohsis and alcohol abuse. Since a confirmed diagnosis cannot be given on net please discuss these possibilities with your doctor once. Hope this helps. Take care!



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