Medical Questions > Conditions and Diseases > Epilepsy Forum

Does either Depakote or Keppra affect growth?

I was just wondering if anyone has any evidence/knows of any studies that suggest the anti-epileptic drugs Depakote (Valproic Acid) and Keppra (levetiracetam) affect height growth in any way? Thanks.

P.S: I came across this article: http://jcn.sagepub.com/content/19/1/26.sho rt
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First Helper pwvillalta
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replied February 6th, 2012
Depakote-slowing growth rate
My daughter is 13 and has been on Depakote since she was 9 years old (3rd grade). At the start of 6th grade she weighed exactly the same as she did in 3rd grade and had only grown 2 inches. On average she should have been growing 2 inches per year (3 years=6in.). I am not sure if it was actually the Depakote or the fact that she slept terrible on Dep and never really fell into a deep sleep which is when growth hormones are formed. The Drs. just added Keppra and she is sleeping like a champ. Hopefully we will see a spike in her growth now that she is actually falling into a deep sleep.Keppra has done wonders for her sleep and she stopped having crazy dreams.
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replied February 9th, 2012
I appreciate the reply. My growth has slowed since being placed on meds a few years back, but I was in a fairly advanced stage of puberty at the time so its likely that is the reason for my halted growth and not the meds I am taking. I wish you and your daughter luck with the added Keppra and with epilepsy in general. I personally have experienced no discernible side effects while on Keppra; I feel most of the horror stories regarding "Kepprage" are hyperbole and blown out of proportion. If your daughter experiences any more problems/issues regarding growth, feel free to again post in this thread as I would be interested in knowing (though I completely understand if you wish to end our conversation here since these are private matters). All the best.
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