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My depression seems to get worse whenever I take medicines that elevate serotonin levels. I seem to respond the best to SNRI medicines like Effexor XR and Pristiq. I have never tried Desipramine, yet one doctor a couple years ago suggested it may be a good alternative for me.

I am usually taking Focalin tablets 40-50 mg a day under psychiatrist prescribing, yet I don't think that my depression is managed well enough. I am taking the Focalin more for ADHD, but I am uncertain if it is safe to take the Desipramine and Focalin together as hypertensive issue is a big concern from what my doctor says.

I don't really like exercising much, but I do sometimes ride my bike outside and go lift some weights with my friends. I do drink a little bit of alcohol, but it is only in moderation and on certain occasions.

I am usually tired, unmotivated, and haven't found psychotherapist to be very helpful. My psychiatrist kind of does therapy better, yet I cannot see him all the time he's busy

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replied February 1st, 2019
Depression Answer A64776
Thank you for asking at Ehealth forum!

I read your question and I understand your concern.
Desipramine should not be used for more than 6 weeks.You would need support group, mind relaxation excercise like yoga and meditation and psychotherapy sessions.
I hope it helps. Stay in touch with your healthcare provider for further guidance as our answers are just for education and counselling purposes and cannot be an alternative to actual visit to a doctor.
Take care

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