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Why might stimulants (such as caffeine, methylphenidates, amphetamines) all cause me to experience fatigue but then several hours later after taking those I will take Zoloft/Sertraline, and I will feel a rebound in energy and wakefulness.

Isn't this backwards? I frequently experience these kinds of "paradoxical" side effects and other atypical side effects like those that no doctor/no pharmacist has ever been able to help me understand.

It really would be nice to have a definitive explanation for some of these random phenomenons I get from medicines besides everybody reacts differently to different medicines.

I mean, there has to be a reason(s) somewhere, right?

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replied December 8th, 2018
Chronic Fatigue Syndrome Answer A64645
Thank you for asking at Ehealth forum!

I read your question and i understand your concern. Ssris are non stimulants and potentiate the effects of stimulants. If you have been prescribed these meds for ADHD then find other wise self medication would be unwise.

I hope it helps. Stay in touch with your healthcare provider for further guidance as our answers are just for education and counselling purposes and cannot be an alternative to actual visit to a doctor.
Take care

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