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Castleman's -"Shattered glass" lymph nodes

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I was just dx with Castleman's on 11/10/2014 after a lymph node was removed to rule out Lymphoma. They were working toward a dx of Churg Strauss after a recent hospitalization with respiratory symptoms, SATs were 88-90% on 2 liters of O2, my Eosinophils were off the charts. A CT scan showed as my pulmonologist described as "Shattered glass" lymph nodes over most of my chest and abdominal cavity. My IeG lab a month after Prednisone step down treatment was 797. My next step is a repeat CT this week and an appointment with an Oncologist on Monday. My question is after reading up on the Castleman's disease I don't see anything about the elevated Eosinophils could I possibly have 2 auto immune diseases going on at the same time?


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replied November 13th, 2014
Blood Disorders Answer A50029
Thank you for asking

Mayo clinic is a rare lymphoproliferative disorder and it presents this way, surgical excision would have been wise in case of localised spread, but as yours is spreading at a wider frame so i believe it will be managed conservatively.

And eosinophils may rise in it too and just eosinophils suspicion to be reason for another autoimmune is vague and unlikely.

Monoclonal antibodies, Antiviral drugs, Thalidomide and corticosteroids are some of the options along with chemotherapy.

Good Luck


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