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brain mets gone - now in liver

My wife had breast cancer in 2003- masectomy, chemo (FAC & pacti taxel 4 cycles each) and radiotherapy. was good for over 4 years. Metastatic cancer in late 2007- mediasternal lymphnodes and bones. Took TCH (Her2 positive) upto March '09. Mets in brain as per PET Scan in May last year WBRT and XELODA- Tykerb therapy, both for 6 cycles and Tykerb alone after Dec '10. Now has mets in the liver, bone cancer intensity up, adrenal gland, perigastric lymphnodes,bilateral hilar lymphnodes.
Is it ok to restart XELODA along wih Tykerb again or should she take some other chemotherapy. 56 years old.
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replied April 13th, 2010
I am very sorry to hear of your wife's advanced breast cancer, and I wish that I had something helpful to suggest to her. You did not mention whether or not her original breast tumor was sensitive to estrogen (or not), but if it was ER-positive, then she should probably be placed on an aromatse inhibitor.

As for recommendations regarding additional chemotherapy, only her treating medical oncologist would know which (if any) of her previous chemotherapies were effective, and so I cannot really offer you any specific advice on chemotherapy. (You might also ask your wife's oncologist about any clinical trials that she might be eligible for.)

I hope that you and your wife can find an effective therapy for her breast cancer.

Sincerely/ Robert A. Wascher, MD, FACS

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