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Avloclor & Paludrine in first trimester

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I have been on holiday in Goa from 08.11 until 23.11 and have been taking Avloclor and Paludrine antimalarials.

I have now discovered I am 6 weeks pregnant.

The first date of my last period was approximately 31.10

I have received mixed reports regarding birth defects and would like to know the risks associated with the 2 antimalarial tablets. I believe Avloclor sites birth defects are possible. Is there any way this can be detected from a scan? Are the risks high? I have stopped taking the Avloclor and would have only had 2 tablets left to take. I believe Paludrine has been reported as o.k. I am very very worried and would appreciate some guidance and help
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replied December 18th, 2008
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Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.


Malaria in pregnant travellers increases the risk of maternal and neonatal death, miscarriage and stillbirth, and pregnant women are advised to avoid visiting malarious areas if possible. When travel cannot be avoided, it is very important to take effective preventive measures against malaria and be extra diligent with measures to avoid mosquito bites. Proguanil and chloroquine (Avlocor) have a long history of safe use during pregnancy, but they should only be used after seeking medical advice from a doctor. It is recommended that pregnant women who take proguanil also take a daily 5mg supplement of folic acid.


Chloroquine and proguanil pass into breast milk but are not harmful to a nursing infant. However, the amount of medicine that passes into the milk is not sufficient to prevent malaria in the nursing infant. The child will also need to be given antimalarial medicine, and you should seek medical advice from your doctor or pharmacist with regards to what medicine and what dose to give.

You are fine, do not fret. The risks of Malaria outweigh potential risks of the medicine. From what I have researched, there is no evidence that Avolcor causes birth defects. Just please please please take the folic acid. It is recommended anyway for pregnant women. I apologize for it taking so long for a reply. I also looked up Paludrine and that also suggests taking folic acid and does not show any risk of birth defects. It does say on both medicines to keep continuing taking the pills until the course is finished.
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