I started taking it on Sunday 7/22/12 and I noticed after a week to two weeks tremendous results. No more negative thoughts! Little things that upset me no longer do and for me it's like, "Ya know whatever!" and I just roll with things. I also have no negative thoughts toward persons in general. IT also allows me to slow down situations when a disagreement occurs and it allows me to think without acting impulsively. I'm not sure about the focusing part though. Not sure if I have seen an improvement in focuse. I have had no side effects and I'm currrently taking 250mg/day. I am a type 3 Overfocused Adult ADD case.