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What does long-term isolation do to a person?

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If someone has been isolated for a long time, they don't have any friends. What effects would this have on a person? Where would this lead to?

Your opinions or experiences please?
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replied May 28th, 2012
Active User, very eHealthy
I've been mostly alone for a long time.

It doesn't have much of a negative effect on me, I don't desire to be sociable, it's a rediculous thing to me and full of lies and deciet.

Be careful what you call a friend.
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