I have agitated depressive symptoms, Fibromyalgia and very stubborn Pre-menstral disphoric disorder. I recently stopped taking Effexor due to extreme constipation, low sexual drive and weight gain. In the last two weeks I have been on 150mg and have gone up to 300 WelbutrinXL. I have more energy, which I like but I am having trouble sleeping, feeling jittery and worried that if I don't get enough sleep my fibromyalgia symptoms will worsen. I have been told that Cymbalta is helpful for fibromyalgia but still worried my jitters might continue and I really do not want to switch meds again if possible. I am trying to conquer the jitters and insomnia right now by taking more amino acids- L-Theanine and 5-HTP. A friend, with similar depressive symptoms, said maybe taking Welbutrin in the am and cymabalta in the pm might be better. Would you recommend a good combination for depressive symptoms and fibromyalgia that won't cause weight gain and would help me get some sleep?