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Q: Weaning from MAOI antidepressants
asked by: jazzfan on June 2nd, 2009
New User
I am wondering if anyone has had experience coming off MAOI antidepressants after long term use. I am currently weaning from Nardil (with medical supervision) but am having a really hard time. I am very sick with physical withdrawal symptoms.
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Suzana_del_Sol
replied on June 13th, 2009
Experienced User
Maybe you could take some vitamins. It help some. Try fish oil supplements. I have not experienced that, but I did experience alot of irritability when coming off Xanax. It went away after a while though. Can you lower the dose? Try taking a little, and lessen the dose as the days go by. It will be alot easier for you that way.
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rosedeb
replied on June 29th, 2009
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I was on Nardil for 18 years and had to wean off it starting Nov, 2008. I was taking 60mg when started weaning, but my doc had me titrating too fast (1 pill every 2 weeks) so by the time I got to 2 pills a day, I was experiencing extreme anxiety and fear. We increased it to 3 pills a day and stayed on that for 2 months when started to wean off again, this time 1/2 a pill a week. I have been completely off Nardil since March 2, 2009, and I am STILL sick! I have been nauseaous for 6 months, obviously, making it hard for me to eat much. I've lost 45lbs (though I did need to loose it - just not that way!). The nerves in my feet are screwed up and extra sensative, and I generally feel unwell. I have not been able to work since March and every time I've tried to get on a new anti depressant (with doctor) I have to stop because it makes me more sick. I'm presently trying Emsam (MAOI Patch) but have only been on it for 1 week today, but this past week has been one of the worse.

I don't know at what stage you are at weaning off Nardil or if you are completely off, but if you are not, I would highly reccommend that you wean the rest of the way VERY slowly! I read where someone actually cut back 1/4 pill every two weeks and it took him a year to get completely off the med! But he didn't experience the horrible effects of going off it! I'm getting so discouraged and depressed being sick this long that I'm wondering if I have to go back on Nardil to stop the cycle and then re-wean off it again, but this time much slower. Only problem with that is I'm afraid it wouldn't work and I'd have to start all over!

I hope that you don't have to (or haven't had to) suffer like I and others have upon going off Nardil. I am almost certain that it's because of the formulary change in 2003. I weaned off Nardil at least 2 times prior to this time before 2003 without any problems!
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jazzfan
replied on June 30th, 2009
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At my highest dose, I was at 90 mg per day. I was weaned in hospital a little over 2 years ago...much too quickly...and got very, very sick. The nardil was reintroduced to 75 mg. I took a few months for the nausea to disappear completely but it did.

This time I reduced my daily dose by 15 mg per week. I did ok till I got down to 30 mg and then got sick again. I tried to ride it out but after no change in about 3 weeks I reincreased the nardil. I got back to 60 mg. before I started to feel any better. That was 2 months ago. I'm much better but still struggling with mild nausea. When the nausea completely resolves I will begin weaning again.

This time I intend to wean, not based on DAILY dose, but on WEEKLY dose. At 60 mg/day I'm taking 420 mg
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jazzfan
replied on June 30th, 2009
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...cont per week. My first reduction will be to 405/ mg per week. I will take 4 pills on six days and 3 pills on one day. I hope to continue reducing by 15 mg from the total weekly dose every week until I'm completely off. IF this goes as planned, It will take me 28 weeks to get off.

Thanks for sharing your experience. There is a definate consensus that the newer formulation is far more addictive than the one we started taking back in the 80's.
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rosedeb
replied on June 30th, 2009
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Wow, this "new nardil" sure messes with the body! I wish you the best when you try going off it again. If my docs put me back on it to get rid of the nausea, I plan on weaning of SUPER SLOW - like reducing by 1/4 a pill every 2-3 weeks! IT may take a while, but at least I shouldn't get sick. However, at this point, my doctor doesn't want me to go back on Nardil becasue she doesn't want me to have to go through the withdrawal process again. SO far today has been the first day where I've actually been able to eat without nausea in 6 months! Maybe it's starting to go away on its own - though I hate to say that out loud, you know? lol
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pcarbary
replied on July 19th, 2009
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It's so nice to talk about weaning off MAOI with knowledgeable people. My psychiatrist knows nothing about MAOI's - I told him I had success back in the 80's with nardil (now on Parnate) and he prescribed it to me. Nothing else works for me. Does anyone know if, like nardil, parnate has a different formula?

I increased my normal dosage because my doctor, like all of theem, insisted I get off a high valium dosage. As I increased the parnate dosage, which my doctor had no problem doing, it really helped me wean off valium. Now I'm on 70 mg a day and its effecting my memory (I've never seen that as a side effect of MAOI's - am I the only one?)

SO now, I want to wean myself off Parnate...of course I have to figure this out myself since my doctor doesn't know crap. I'm starting off by taking 1 mg. less per day, then if I get depressed during the day, I take 1/2 mg at that time. For some reason, parnate acts really fast on me, almost like aspirin, and it helps, but I've noticed it also sedates me too much during the day. If I wean myself off normally, I get depressed - again a symptom I haven't read about in people. I'm feeling nausea as well and less appetite. I did recently notice that.

I've heard the longer you're on it, and the higher the dose, the more difficult it is to wean yourself off. I've been on it for about a year and a half, steadily increasing my dose to 90 mg. at the max though I had almost no short term memory and had to quickly decrease it. In the 80's I took nardil, about 30 mg for two years. As I recall, it lost its effectiveness so I stopped. But is was not a problem to wean off of at all.

When I take parnate at night, I get wired--it effects my sleep, another reason to get off it. Again, my doctor is clueless...anyone else get this?

Anyway, I'm glad I found this forum. Please feel free to private message me here. It would be nice to be in touch with other MAOI users trying to wean themselves off it.
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