As you seem to know, there is a known risk of high blood sugars occurring with the use of seroquel and other drugs like it. Looking at the medical literature, high blood sugars are most likely to appear in the first six months of use.

The exact cause for the high blood sugar is unknown - factors such as weight gain, increased resistance to insulin action, and high triglycerides may play a role.

I think speaking with your doctor is the right route to go in your case. This will allow the two of you to weigh risk and benefits of using seroquel in your case. You and your doctor should also discuss methods to monitor for risk such as checking blood sugar readings at home using a glucose monitor.