Have the doctors run any scans to check for blood loss?

They must be monitoring his blood through tests, it would be a good idea for them to go for another opinion.
As you mentioned he might know and does not want her to know. If this is the case can you talk to him and tell him how worried his wife is, that she is scared? He may think he is protecting her by not telling her what is really going but in the long run it's hurting her more by not knowing.
If he does know the other thing is can this problem be inherited, if they have kids, it would be good know.
Did his parents have any type of problems like this?

all I know is that supposedly once a year he goes in and has blood transfussions. it makes no sense to me as he returns home at the end of the day. He is working. Supposedly these treatments last for a year, but last one onlyfor a few months.

Supposedly doctors told him he was going to die but have no idea what the problem is Supposedly a "research doctor" is working on this.

Why I am confused is if a doctor tells him he doesn't have to much longer to live and has lived longer than expected, they must have some idea of what the problems are and what he is going through. This makes absolutely no sense to me.

She told me once the doctor told him he would not survive much longer his health insurance plan cut him off but reinstated him when he didn't die. This whole story is suspicious to me or I am missig something. A health plan would perhaps deny payment but not cut him off and reinstate insurance because he didn't die.

I have some reason to believe he may be homosexual and am wondering about AIDS due to her reluctance to say. if it is then I have reasons to be concerned. But she is upset and tells me so. But there has to be more to the story,

Is there any way you can talk to him?

Is he taking other medications such the med's used for HIV/AIDS?
Maybe if you told your friend and reassured her no matter what he has you will be there for her, if in fact he has AIDS maybe she is reluctant to tell you, I believe in time she will tell you maybe she is afraid of how you will react if this is the case.

I can see how concerned you are and I think it's wonderful that she has you.

there is no way I can talk to him, nor would I desire to do that. I am more concerned for her. Alll I know is that he is on some type of medication that could cause birth defects as she told me and he had to undergo a vsectomy two years ago.

there was some mention of prostate problems.... but she says docotrs do not know what is wrong with him. i am at the point I am having trouble beleiving the story but she has always bee honest with me which is why i am confused.