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Uloric ? (Page 2)

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September 10th, 2009
Oh that's horrible! Shocked So sorry to hear that. Yes, these drugs can have nasty after effects. Need to keep an eye on them. I've finally overcome a minor flare on 40mg. Worried about jumping to 80mg as suggested earlier.

I wonder if the muscle cramps will not get out of control. I have two weeks to decide. Then I can either stay with 40mg, up dose to 80mg or go back to Allopurinol. Rolling Eyes
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replied September 13th, 2009
I just wanted to post today about my husband and all the people that are taking a new drug called Uloric. We call the company that makes the drug because my husband was taking 80MG and was getting so many gout attacks but this is how they explained it. While you are taking this drug it gets in and moves the crystals around till there are none left. He has been fine for about 1 month now. He is on a maintanence program. 40 MG of Uloric, the pain reliever Indomethacin 2 a day, a 1 colchicine, and lot of water. Keep the faith because we really were getting discussed and now I think the worst is over.
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replied September 21st, 2009
New Uloric user- Age 25
I'm a 25 year old male who was diagnosed with gout about 2 years ago. I just had a huge flare up last saturday. I endured the pain for a few days, then took ibuprofane and some black cherry/ regular cherry pills/extract. I just saw a doctor last friday and he gave me uloric and Limbrel. The gout attack was originally on my left foot. It was healing up prior to the doctor's visit. After taking a dose of Uloric, my right food immediately began to throb. It is now Monday morning and my right foot has flared up so bad that I'm unable to sleep. I know this is a side-effect of Uloric since it could potentially result in gout flare ups as it tries to extract/destroy or do hwatever to the crystals built up in my joint. Any other suggestions as to what I can do? I have missed an entire week of work, and with this recent flare up it looks like I'm done for another week....
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replied September 30th, 2009
I'm a 31-year-old female, and have been plagued with gout since my teens. Had a severe allergic reaction to Allopurinol in college (almost died) and since then have tried indomethacin for flare-ups (worked for a while, then had no effect), and colchicine for prevention (on it once daily). However, the only treatment that works when I have a flare-up these days is prednisone. Thankfully, I only have to be on it for about a week, but it works its magic. My doc just prescribed Uloric and while I am anxious about the side effects of flare-ups when you first start, I'm excited hearing all the good stories posted here. If it will clear our the old crystals that have built up in my joints, both hands and both feet, I'll feel reborn! The almost monthly/every two months flare-ups since my teens have caused serious tophi and made my feet grow from a 7 1/2 to a 9 1/2! Plus the daily stiffness in all joints and "old lady" hands at 31...well, wish me luck! And good luck to all of you out there giving it a try. About time they came out with something new...it only took 40 years!
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replied September 30th, 2009
I have posted before about my experience but I would like to update.
Please use caution with Uloric. I am not saying it is the reason but I have been on it three months and it is magic as far as uric acid numbers. But after a lifetime of good blood work (except for uric acid) my life has been turned upside down. My kidneys are failing. I have stage 3 failure. Still finding out how much longer I have but suffering many of side stage 3 side effects.
So please people use caution.
Smile
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replied November 20th, 2009
Details, details.
Experimenter - have you had your uric acid levels tested? if so, how did the uloric affect the results?
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replied November 20th, 2009
Re: New Uloric user- Age 25
uncompromising wrote:
Any other suggestions as to what I can do? I have missed an entire week of work, and with this recent flare up it looks like I'm done for another week....


Find a Dr. that will prescribe you prednisone. Shouldn't be too difficult. It isn't something you want to be taking all the time, but if you need an attack to go away as fast as possible, you should try it. It works every time for me, usually within 12-18 hours. Just make sure you surround yourself with HEALTHY snacks that fill you up, like veggies, fruits, etc. because prednisone will make you eat like a bear!
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replied November 24th, 2009
Hello folks, I just "celebrated" my one year anniversary of a recurrent ankle "sprain" that was finally diagnosed as gout. Apparently I have had gout for at least 6-10 years, and how it finally exploded into my knee, elbow, fingers.

Long story short, I have been on Uloric for about 5 months, far better tolerance than Allopurinal. UA level has been under 6 since 2 weeks after starting Uloric. Yes, I had many many flares during the first 2 months of taking Uloric. Those attacks were minimized/ mitigated with Colchicine and Indomethacin. I find myself still needing to take a colchince every 7-8 days.

Now I have no pain at all in my elbow and fingers. I have some pain inside of my left knee joint (which showed tophi during joint aspiration) and I still have problem with my chronic ankle sprain with tophi (you can't see it from looking at my ankle). I am counting on my doctor, who assured me with longterm Uloric intake, those tophi will be dissolved and get re-absorbed.

I will get another lab test next month, the first 2 showed UA to be in target range of under 6mg/dl, and the next one will be testing my liver and kidney function. I know if the lab comes back with failing kidney like the other post, I am definitely going to seek alternatives. At $5 a pilll for the 40mg Uloric, it will only be worth it if I am not sacrificing my other organs. I am 47 yr. old and plan on staying here a while longer!
Anyway, I found this forum and hope I can learn as well as share my gout experience with you all. Best of health. Wen
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replied November 24th, 2009
Uloric Gout
I have had Gout for 23 years (first noticed it the year after I left USMC at 22, 45 now). I started taking Allupurinol when I was 30. I took it religiously but never had a uric Acid level below 7. In August, my Dr put me on Uloric. I took the 40 mg dose for two weeks and had a Uric Acid level of 7. I switched to the 80mg dose for two weeks and have a Uric Acid level of 5(woo hoo). I am continuing on at 80mg/day. I have had several attacks. I control them with Indomethecin; however, I am taking that more than ever in the past (due to attack frequency). I am hoping that the pain I am going through will lead to better joints/less pain in the future. I will report back as I get more data.
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replied November 24th, 2009
jjarvis72, that is kinda like where I am at. I am taking the Uloric faithfully, but still have to deal with the flares. I must admit my good days are better than before Uloric, and the bad days are not as bad.

I am having a flare today! Its always a downer when that happens. Painful enough to have a slight limp, but not so much that I have to lie down.

Gout sucks bad!!!
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replied November 25th, 2009
wwp512, those flairs sure have an impact on quality of life after a while. I don't think a day goes by anymore where i don't have some kind of joint pain. Ankles and Knees are so full of Uric Acid crystals there is no short term solution there. I am really hoping the pain will be worth the gain. At 45 I should be contemplating something crazy like a marathon. I have trouble walking from the car to the curb. It is not where i imagined myself at this point. So, I will stop complaining. I am glad to hear you are seeing a small improvement. I am not sure i see that yet but it isn't any worse. I hope to hear that others are doing well and seeing signs of reversal in symptoms.

Gout sucks bad...I agree!!!
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replied December 3rd, 2009
a follow up on my lab test after about 5 months of being on 40mg Uloric daily.

My kidney is ok, but liver ALT and AST are both up, to the point my doctor wants me to gradually get off of it!

Beware!!
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replied January 3rd, 2010
To everyone, go to Posted "second gout attack" or "gout and baking soda" then look under "gout help" this remedy will work for you. This remedy is something that your going to have to do for the rest of your life everyday to pervent gout and flare ups. Once you've had gout you'll always be prone to it. I've done all the remedies, gone to the doctors and all they give you is perscriptions drugs to help it go away after it's already flared up. Allorpurinol helps pervent it but once gout flares up, allorpurinol won't stop it and it's like taking rat posion. Read both remedies, I've just worded them differently. Have a gout free life.
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replied January 6th, 2010
what I've learned about gout
Hi all. I've had gout for a long time and just started on Uloric today. I tried Allopurinol months ago but was allergic. I've been unable to walk without a cane for the last 6 weeks and spent the better part of the holidays researching gout. I'm not an expert, but I'll share what I've learned in the hopes that it may be of some help to someone; there is a lot of misunderstanding about gout.
* Another excellent place for info about gout is the web site gout-pal.com. Its a forum and many articles- they aern't selling anything. Fellow gout sufferers with some excellent free information.
* Gout is all about Uric Acid levels. Above 6.8 and UA can crystallize in the joints and cause gout(at body temperature- lower when colder like in the extremities- feet-- thus the goal is to be below 6.0)
* gout requires two kinds of treatment. 1- reduce UA levels (this is likely best done with the less expensive and more proven Allopurinol, but Uloric is another new option. There is one other one but I don't recall the name. Both do cause flare ups until the UA gets below 6.0 as indicated here. It is the reducing of the UA that cuases the flare up (I guess there is a coating on the crystals that the meds first wear down- then the immune system attacks the crystals and cause inflammation and pain) Common problems: a) people stop taking it due to flare ups initially, b) people don't take a high enough does to get below 6.0 (go to Uloric.com and their site explains the recommended dosage of 40 mg for 2 weeks and if UA is not below 6.0 increase to 80 mg); c) people don't treat the pain while getting the UA levels down.
2- the second kind of treatment is treating the pain and inflammation. this is commonly done with colchicine, indomiethine (spelled wrong), ibuprofein, prednisone, ice packs alternated with heat, etc. Problems: too many doctors only treat the symptoms and not the underlying problem to get the UA levels down. Do that and if you are lucky enough to get over this flare up, you'll be revisited again later by our friend the gout- more frequently and more severely as the years go on. Uric Acid builds up over months and years- not fluke flare ups that then go away and never come back. Hover a little above the 6.8 level and may have intermittent or no attacks- eventually get too high (I'm running between 9.1 and 10.0), and you'll have chronic gout pain that will not go away--until you get your UA levels down.

Gout diets, lots of water, exercise, healthy BMI can lower UA and eliminate gout if you are not too far above 6.0-6.8. These alone can typically only reduce UA levels by about 1.0, so if you are in too bad of shape, you'll need to get on meds to get your UA levels down. For me some herbal remedies like cherries and apple cider vinegar helped temporarily, but ultimately, my UA levels were just too high to manage without medicine. Baking soda works for some people too. There's some science behind all these- they help balance ph levels which helps eliminate UA, etc, but they won't work if your levels are severely high and/or there is another reason your body is not effectively eliminating UA.

Rheumatologists are the specialists that know the most about gout, so if you seek medical help, that's your best bet.

Anyway, hope this is of some help to fellow gout sufferers. I'm not a medical expert, so if I got anything wrong, feel free to correct me.

I know I have to get my UA levels down below 6.0 or I will never cure my gout and I'll remain crippled. I'm hoping the Uloric will work. I'll be on prednisone and colchicine to deal with the pain while its working and hope for the best. (I had a kidney transplant 15 years ago and cannot take ibuprofen).
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replied January 7th, 2010
Uloric vs. Allipurinol
Hi all, It's good to see there is a site where others understand the pain of this beast. I have fought it for 40 years know ( I'm 60)and I'm not sure you can ever beat it but you may be able to control it. Over the years I have taken 1000's of cholchicines and Indocins and recently way to many prednisone ( they really scare the crap out of me but they seem to help) when used with the others. I never really used allipurinol as I was never clear enough to start it without extreme attacks taking over. About 6 weeks ago my Doc. gave me some ULORIC 80mg and at that point I would try anything, was just getting ready for a heart bypass, I have been taking it ever since with minimal side effects. I had my liver and kidneys checked last week and they were fine, I also had my acid level checked and it had dropped from a 7.8 to a 3.2, I have never been lower than 7. Having said that I had a quick attack last night but I think I have it under control today with indocin(25mgx2 daily) and predisone(5mgx2 daily) and cholicine(.6mgx1 daily), this typically works for me but as you can see even with a proper acid level (3.2) you can still get attacks. I have had probably 3 of these minor attacks over the six weeks so I guess I am lucky so far. Over the years I have had it in almost every joint in my body, suffice one, and my right index finger is severly demented. Uloric is very expensive as it is new but if it stops the attacks, without destroying the rest of me, I'll pay anything. It sounds like most of these drugs effect us all somewhat differently and I wish you all the best.
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replied January 11th, 2010
My spouse started taking Uloric in September. Never took Alpurinol, but had a Uric Acid level between 8-10 for at least two years. He's had gout much longer than that - 10 years? Uloric brought the uric acid level down to just under 6. He missed a few pills two weeks ago and last week had his first attack since September. This morning he woke up with a minor attack - just a swollen foot, but no pain. He's been back on the Uloric faithfully for at least a week.

Thankfully, after reading this site I'm thinking that his "flare" is probably still tied to the fact that he missed some pills. Perhaps some crystals began building again and now they're moving into the bloodstream. Or is it more likely that because he's so close to the "6" cutoff that he's bound to have attacks now and then, even while taking Uloric?
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replied January 18th, 2010
I wish you the best. I have been struggling with gout for 15 years and at 49 I am really tired of being in pain every day of my life. I have been to many doctors, the arthritis doc sent me to the internal med doc, he sent me to the orthopedic, he sent me to the arthritis doc, etc..etc... I have another appointment today and hopefully this doc will be some help. I am desperate for a doctor that really wants to help me. I have gout in every joint in my body and my hands are becoming useless with nodules and deformity taking over. Can anyone recommend a good gout doctor in southeast N.C.? Thanks.
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replied January 21st, 2010
I just wanted to share what I've learned about gout in the 18 years I've had it. Most of which I've really only learned in the past 2-3 years

First, never take low-dose aspirin if you have gout. Normal dose is OK, but low dose is almost sure to kick off an attack.

I learned this the hard way after I left the hospital after a mild heart condition in 2006. One of the several things I was prescribed was low dose aspirin. I could not believe the pain after only 1 day home. I was trying to figure out which of the things I was taking could cause it as I hadn't had an attack in several years. I then googled "gout" and "aspirin".

I told my Dr. and he pretty much said I was on drugs. After he researched it he apologized and said that I was right on the money and he had never heard that in 25 years of practice that low dose will kick off an attack.

Next, do NOT take idomethacine if you are on coumadin or warfarin. Not if you want to keep your stomach anyway. I had an aortic valve replacement surgery done in 2007 and I told the nurses after no low dose aspirin and no indomethecine as they are not compatible with gout and warfarin. They tried to give it to me anyway and it darn near ripped out my stomach. The only thing I can take, in small quantities, that does work in an attack is Celebrex.

Now, what I have found out was the cause of my gout, and I'm 100% certain on this, is I've had sleep apnea for years and did not know it. My sleep was finally getting so bad that I begged my Dr. for a sleep test on 2007 and after the test I found out I had severe apnea.

Once I got used to my bipap machine at night, I can sleep great and guess what, no more gout attacks. I swear that if I'm off the machine at night form more than 3 days (on a trip) I start getting attacks. Once I go back on the machine at night, no more pain. Google "gout" and "apnea" and see what you find.

Again, this is just what I've found out about my personal condition, it may not be true for anyone/everyone else. But, if you've had gout for a long time and can't figure out why, check into the sleep apnea problem.

One other thing, if you are taking allopurinol for maintenance, please stop taking it as soon as you have an attack. Only start again after the attack is done. That's another one I had to explain to my nurses AFTER they gave me the low dose aspirin and the indomethicine.
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replied January 21st, 2010
Hi, someone of you know if sildenafil increase de acid uric level?
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replied February 2nd, 2010
I was prescrived Uloric today and so afraid to take it since one of the side effects is the onset of a possible attack. I am just getting over one and so afraid to have another. I plan to travel abroad in less than 1 week and was thinking perhaps i should begin to take it after my vacation. Any thoughts or ideas? Greatly appreciate any insight.
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