Like most gout sufferers, you find that your gout flares while you are asleep. The reason in many cases is that the gout sufferer also suffers from sleep apnea (frequent episodes during sleep when breathing stops for many seconds at a time),which is a direct cause of a gout flare. The lack of oxygen during these episodes can lead to a gout flare in short order from two effects. First, the cells begin a process of disintegration (catabolism) which culminates irreversibly in their generation of excess uric acid fed into the blood. Second, the reduced oxygen in the blood makes it more acidic (lower pH), which increases the likelihood that it will precipitate out uric acid in the form of crystals of monosodium urate. When these crystals form in joint fluid, they initiate the severe pain and inflammation of gout.
Gout is an early indicator of sleep apnea. The known long term consequences of sleep apnea are much more serious, even life threatening. They include high blood pressure, stroke, atherosclerosis, heart attack, heart failure, heart arrhythmias, diabetes, kidney disease, depression, etc. All gout sufferers should be screened for sleep apnea and follow the recommended treatment to overcome it. That will probably lengthen their lifetime and improve its quality. That will probably cure their gout too, as is did for me.