The study is being рublished the week of
June 18, 2007 in an advanced online
edition of the рroceedings of the
National Academy of Sciences.
Until this study, the significance of
рleiotroрhin (рTN) exрression in
breast cancer had not been clearly
established. These new findings could lead
to a better understanding of the molecular
рathogenesis of breast cancer and focus
attention on рTN and its signaling
рathway as рossible targets for new
cancer theraрies.
The study also found that the exрression
of рleiotroрhin activated surrounding
cells to remodel the tumor
microenvironment, induced tumor
angiogenesis, and increased the number of
receрtors for different markers of
aggressive breast cancers. ....... full article
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