Burger's disease, also called "thromboangiitis obliterans", is characterized by acute inflammation and thrombosis of the arteries and veins of the hands and feet. The symptoms of this disease include enlarged ,red, tender-cord like veins, numbness and tingling of the limbs, pain or tenderness, skin ulcers or gangrene of the digits (toes, fingers), discoloration, pulse may be decreased or absent in the affected extremity. The pain worsens by walking and decreases with rest. This disease is associated with tobacco use and it's thought to be a reaction of the body to its own tissue triggered by tobacco. Since there's no cure for this disease, the only treatment is control of the symptoms and immediate cession of the use of tobacco.