Would like to get some help in trying to
understand this report in layman term. Can
someone help me please? (is as below or
you can download it)
At the same time, please give me some
opinions in terms of medication and also
what are the available treatment for such
diseases. Thanks.
Nature of Specimen: Right Colon
Gross Appearance:
Segment of intestine, composed of terminal
ileum measuring 30cm in length and 5cm in
broadest diameter, with 4cm diameter
proximal surgical margin, appendix
measuring 7.5 cm in length, 1.5 cm
diameter and distended caecum with colon
measuring 27cm in length and 10.5cm in
broadest diameter. The distal surgical
margin measures 3.8 cm in broadest
diameter. The serosal surface of the
terminal ileum is studded with whitish
nodules, the largest about 3mm in
diameter. Several nodules are seen in the
attached mesentery, the largest being 2.5
x 2 x 1.5cm at the apex of the resection.
A constricting tumour mass is present at
the lower end of the caecum and proximal
colon measuring 6cm in length involving
the entire thickness and circumference of
the colon measuring 6 cm in length
involving the entire thickness and
circumference of the colon wall
constricting it. It is situated 6.5 cm
from distal surgical margin and 14.5cm
from the ileo-caecal junction. The
appendix is thickened and congested.
Several node varying in size from 1mm
diameter to 1.5 x 1 x 1cm in broadest
dimension are present in the pericolic
tissue.
Representative Sections:
Block 1- Proximal end of tumour
Block 2- Full thickness of tumour
Block 3- Distal end of tumour
Block 4- Full thickness of tumour
Block 5- Nodules on the serosal surface of
ileum
Block 6- 7- Appendix
Block 8- Mesenteric nodes
Blocks 9-10- Largest and smaller nodules
at the apex of mesentery
Block 11-13- nodules in peri-colic fat
adjacent to tumour
Block 14- proximal surgical margin
Block 15-16- distal surgical margin
Miroscopic Appearance:
Sections show transmural infiltraton of
the colon by poorly differentiated
malignant tumour cells with marked
variation of cell size. They have
pleomorphic vesicular irregularly shaped
nuclei, prominent nucleoli and frequent
mitoses. There are large areas of mucosal
ulceration with replacement by fibriniod
necrotic slough and areas of tumour
necrosis. Tumour is also seen with the
submucosa, muscularis propria and serosa
of the ileum. There is transmural
involvement in the appendix, and extensive
lymphovascular invasion in sections of the
ileum and colon. Metastatic tumour is
present in all the pericolic nodes samples
and twelve out of nineteen ileo-colic
nodes including the largest at the apex of
the mesentry. Both proximal and distal
surgical margins are clear.
Interpretation:
Right Colon: Ulcerated poorly
differentiated Adenocarcinoma of the colon
involving the entire thickness of the
wall, extending to pericolic tissues, with
vascular, pericolic and ileo-colic node
metastases Duke’s Stage C.
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wah17
New User, Becoming EHEALTHy
Joined: 27 May 2007 Posts: 2
Medicine & Treatment Posted: 05-31-07 02:26am
Thanks for your detail explanation. i
really appreciate it.
By the way, are you aware of any new
medical treatment for such disease.
Lately, I heard of this drug if not
mistaken is called "tacsiva" what it does
it actually targets the cancerous cells
and eliminates it without having to destro
the good cells.
Besides that, what are the usual treatment
for this case?
