I never recommend Depo to anyone. Since getting off Depo, I have avoided hormonal birth control completely. I was one of the few people who did not gain any weight on Depo, although some of my hair did fall out when I started it and never grew back.
I don't know just how many women on Depo end up with irreversible bone loss. I do know that just within the past couple of years, the FDA said they do not recommend that women, especially young women, take Depo for more than two years unless they can't use other methods of birth control though, and that's enough for me to not use it again or recommend it.