I am in the UK & I take losec which I believe is the equivalent to Prilosec in US. I have never had a problem with these, I currently take 40mg & if having a bad day need to take 2 a day but this is very rare.
I find I can eat most things no compared to before I took them & keeps my acid reflux at bay.
I don't have any experience with Nexium, never heard of it, does it have a different name in the UK?

Have been on Prevacid for the past 5 years. Seemed to stopped working around Nov of last year. Endoscopy revealed gastritis, not ulcers also H pylori.a round of antibiocs fixed this( pepcid and zantac during this period) afterwards was put on Proton. I have not found anything that has stopped this acid reflux, although now that I am taking Prevacid in the am and occasional zantac, up to twice a day, it seems to help. I am not about to pay the insurance premium for the Nexium. You could alwasy try the prevacid along with the zantac? If this does not work, go back to the Nexium. My gastro suggest the others way before he suggest Nexium. Says its a pharmaceutical rip off!

was on nexium for 3 years. ins. dropped any name brands of this type of drug. currently no generic for nexium, so i am high and dry. have tried many others, but no luck at all. nothing compares to the nexium. absolutely the best stuff you can get.