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Conditions and Diseases > Diabetes Forum > Diabetes Mellitus Type 1 Triggers; DM-1
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Q: Diabetes Mellitus Type 1 Triggers; DM-1
asked by: DoctorQuestion on February 1st, 2007
Triggers for T1 Diabetes, I know this is an unclear topic but could a Hepatitis A & B immunisation trigger Type 1? i have done some research to no avail. a few people who worked with me in a large company had this immunisation and were a few weeks later diagnosed including myself, seems to ironic to be coincedence, you think?
Cheers.


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Dr. Nikola Gjuzelov , MD
replied on February 6th, 2007
Diabetes Answer A2281
Immunization against the Hepatitis B-virus usually can not provoke diabetes mellitus type 1. Diabetes mellitus type 1 (DM-1) is considered an autoimmune disease. Beta-cells produce insulin. Insulin is a hormone that has crucial importance in the metabolism of the carbohydrates. Specifically, during diabetes, the beta-cells in the "Langerhans’s islands" of the pancreas create insulin. The immune system creates antibodies and cytotoxic T-lymphocytes against the beta cells. Th precise etiology of autoimmune diseases like Diabetes mellitus type 1 remains unknown. It is assumed that microbes (bacteria and viruses) trigger some types of autoimmune diseases but there aren’t strong evidence that confirm the theory. In the case of diabetes mellitus type 1, the assumed viruses include: parotitis-virus, cytomegalovirus, rubella-virus and coxaci-virus. These viral infections are very common in the normal population, but DM-1 is a very rare disease. This fact leads us to the conclusion that the viruses can cause DM-1 only in people who have a defect in their immune system. In other words, people diagnosed with DM-1 have immune systems that are genetically predisposed to fight against its own beta-cells in the pancreas. Your family data tells me that in your family (mother) there is a predisposition for developing autoimmune diseases (scleroderma).





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