My wife has osteo arthritis & has a lot of pain with it. Recently has been diagnosed with it in her knees. She has used most of the common arthritic preparations such as glucosamine/condriton, celebrex, lacota, nutri joint etc, etc. Her doctor is saying to use tylenol arthritis (maximin dose) during the day & tylenol 3's during the night for sleeping. Does anyone use or know of an effective pain reliever in this case? The tylenol hasn't been too effective.

Thanks