I have been on plquenil since january 2005 and I have actually lost weight. Are you on any other meds that could be contributing to the weight gain? I know that many antidepressants cause weight gain. I was on prozac years ago and gained over 30lbs and it has taken me a long time to get it off.

I have been on plaquenil from june and it is great! It gives me so much energy. I am on prednosin and because of that I want to eat all the time but I have the energy to exercise.

First i'de like to say HI,,,,I'm a new member and new to Lupus as well.To answer your qhestion .....i've been on pllaqhenil for 2 months now and i gained a good 10 to 15 pounds ,,so i guess it does in some ppl ,,Your Docter might be able to answer better though,

As of today, 04/19/09 I have gained 40lbs since being on plaquenil--I started taking it in 04/08 after being diagnoised with an autoimmune disease leaning toward lupus.

OMG I am so glad to see you one here with weight gains , not that I am glad you all are gaining but and so glad to know I am not alone! I am on plaquenil , sulfasalazine and arava. I have gained (over 2 years) 30 pounds, I went off them for 2 months , lost 8 pounds in 4 weeks , went back on and WHAM up 9 pounds.... now what? thanks