It seems that there is nothing you can do to prevent complications caused by spherocytosis because the disease is genetically conditioned. The erythrocytes in your body are more fragile than normal and can be easily broken in the spleen. The removal of the spleen (spleenectomy) is the only treatment available at this time. You can take action, however, and focus your energies into living a healthy life. You can also increase your awareness of infections and keep a safe distance from them.