Hi there mad zappy I have epilepsy and smoke and there is no effect on my epilepsy or my meds . This is from a book on epilepsy this next bit okay can I smoke? Smoking has no effect on epilepsy, but if the individual must smoke then thought needs to be given to safety, for example, not smoking indoors alone or in bed ever. Again this is from a book will street drugs affect my epilepsy? Yes, they may, some street drugs can cause seizures, as alcohol can. The activities that accompany taking them, such as late nights and lack of sleep, can also make seizures more likely. If I can be of more help to you please get in contact with me.