:( I have been diagnosed with sle with kidney disease since 1992 but i've never been very sick - just fatigue and flu-ey feeling. Since summer 2005 i've gradually gotten worse - chest & back pain upon breathing, raynuads illness, weakness, joint pain, fatigue; but the worst is loss of equilibrium and coordination. I know some of this is from the prednisone but I have been lowered to 15 mg. So that shouldn't be the cause. I was thinking it was because I was on cellcept (oct- jan) ; I desperately wanted to get off - it didn't seem to be working and I thought that was the cause of what I was feeling; it's gotten minutely better, but my equilibrim is still bad. At times I have trouble walking, have no balance, and when I try to sit onthe floor I basically fall. I hate it. I was in the hospital, they did numerous mris, etc. And found that I have 2 symmetrical "spots" in my brain. Now they don't think it cancer and they're not in the normal place for cns lupus; they can't make any definitive dx. I can't add or do calculations, and doing things like organizing papers is difficult. Reading has been hard ; my eyes don't want to focus and can flit to look someplace else. It's hard to type, write, and get words out.It is horrible and all i'm doing is waiting. Now my rheumatologist thinks depression and anxiety is getting in my way - now more drugs that seem to compound this. And how can one not be anxious/depressed under such circumstances? I feel its a cop out because he doesn't know what's going on. Has anyone had this type of experience? Any suggestions? It makes sense to me that whatever is going on in my brain relates to my feeling of lack of equilibrium/coordination and some other problems. :( :cry: