Platelets can be low (thrombocytopenia) either because of their low production in the bone marrow or because of their faster destruction in the spleen. The major task of the spleen is to destroy old erythrocytes and thrombocytes (platelets). In some autoimmune diseases the immune system is producing antibodies against these platelets. Those antibodies bind to the platelets’ surface. Platelets with bound antibodies on their surface can be destroyed more easily in the spleen. In such conditions the spleen becomes bigger and more active (hyperspleenism). The pain and swelling you are experiencing on the left side could be caused by this condition. An abdominal ultrasound examination is performed to confirm eventual spleen enlargement. RE: “high protein count”...I need to know WHICH blood protein fraction (alpha, beta, and gamma) is high. Gamma-fraction is increased in autoimmune thrombocytopenic disorders. You will need an expert examination and treatment by a hematologist.