Depekote (divalproex sodium) is an antiepileptic drug; one side effect of the drug is thrombocytopenia. In your sonâs case, it is important to know if he experienced thrombocytopenia before start taking Deprekote and if so, for how long? Your son has been taking Deprekote for 6 years and there is only a slight chance that thrombocytopenia will cause cancer or lupus; these diseases would have manifested some other symptoms so far.