Segawaâs dystonia is a special type of Dopamine-responsive dystonia (DRD). Dopamine treats this disease but it canât be used directly; dopamine canât enter the brain. Instead, the medication Levo-DOPA (L-DOPA) enters the brain and transforms into dopamine in the brain cells. The side effects of L-DOPA are loss of appetite, nausea, vomiting, tachycardia, hypotension, unlikely movements (dyskinesia) and mental side effects (anxiety, depression, insomnia, somnolence, confusion). All these side effects can be reduced by using L-DOPA + a carboxilasa-inhibitor. Further, the side effects are redcuted with temporary cessation of the medicine (âa drug holidayâ).
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