High Blood Pressure, Hypertension, High Cholesterol Answer A
Calcium channel blockers (nifedipine, verapamil and diltiazem) together with organic nitrates and beta-blockers are used for angina pectoris therapy. Calcium antagonists act on angina pectoris in 3 ways. First, they cause VASODOLATATION of all periphery arteries which decreases the peripheral vascular resistance and the heartâs after-load. They also cause vasodilatation of the coronary arteries which provide better blood (and oxygen) supply to the heart. Second, they DECREASE HEART RATE and third, they DECREASE HEART MUSCLE CONTRACTION. These combined effects decrease the heartâs demand for oxygen.
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