I went through a period of low sex drive while I was on depo - but it came back with a vengence really quick lol. Sorry if that's too much info. :)
depo, like any medicine, can have a number of side effects that are different from person to person. The side effects might never show up or they could show up and last only a short amount of time, etc.
I'm sorry you all experienced this on depo.
I also gained weight on depo (about 15 pounds), but looking back I was eating junk and eating a lot more than I should have been eating. It has been difficult for me to lose the weight, but with regular exericse and trying to eat a low fat diet i've been losing about 2 pounds a week for the past three weeks. It's really hard though, a lot harder than I remember from when I wasn't on depo.