Premature ejaculation is a psychiatric rather than a physiological disorder. It is the result of anxiety and stress and is typical in younger, inexperienced men. Premature ejaculation may become a problem if it is present for longer periods of time. This problem disturbs many men's self-confidence and creates sexual dissatisfcation in both sexual partners; premature ejaculation can lead to relationship disturbances also. “Zoloft” is an antidepressant, one whose side effects include the inability to achieve orgasm. Because orgasm is achieved very soon during intercourse for men who prematurely ejaculate, Zoloft can be used to delay an orgasm (ejaculation). “Daproxetine” is similar to "Zoloft" (they both inhibits serotonin re-uptake) but is specially developed for treating premature ejaculation. Daproxetine is still in an experimental phase (not approved by the FDA yet) and remains unavailable to consumers. For prostate pain, you can visit a urologist because it might be the result of prostate inflammation; this can also cause premature ejaculation.