everybody reacts differently to depo, I was answering the post from the experience of having been on depo for four yrs, and after my second dhot I have had one problem after another, muscle spasms, tingling in my face and arms, extreme fatigue, bloating, headaches,pelvic pain, after about shot eight I have double vision with difficulty focusing, joint pain, abnormal pap smear requiring cryosurgery,tendonitis in my left ankle , not to mention minor stuff like not wanting to have sex or the internal pain when you do have sex, my doctors never once mentioned it could be depo , they just kept shuffling me around to specialist for each thing. I didnt get my shot in july 2007 only because my sister said that you shouldnt be on it for more than 2 yrs, {my doc didnt mention that either} I googled it on the internet for the first time in oct just to see when i should get my period, and thats when i found all the other stories like my own , I was horrified, I did finally get my period in oct for 10 days , nov for 21 days dec for 3 and january it was 22 then it stopped for 2 then came back for three more . This is how it has affected me , and many other people , I just think we should be more informed about the effects, other than you might gain 5 lbs, thats about all the pamphlet from the doctors office said, I gained 40 ,